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Von Hippel–Lindau disease ( VHL ), also known as Von Hippel–Lindau syndrome, is a rare genetic disorder with multisystem involvement. [3] It is characterized by visceral cysts and benign tumors with potential for subsequent malignant transformation. It is a type of phakomatosis that results from a mutation in the Von Hippel–Lindau tumor ...
Von Hippel-Lindau disease is a genetic disorder that’s most often inherited, but could also be a de novo genetic mutation. It causes your VHL proteins to be faulty, which then leads to ...
The Von Hippel–Lindau tumor suppressor also known as pVHL is a protein that, in humans, is encoded by the VHL gene. Mutations of the VHL gene are associated with Von Hippel–Lindau disease, which is characterized by hemangioblastomas of the brain, spinal cord and retina. It is also associated with kidney and pancreatic lesions.
Epidemiology. This is a very rare tumor, since only about 1 in 35,000 to 40,000 people have VHL, of whom about 10% have endolymphatic sac tumors. Patients usually present in the 4th to 5th decades without an gender predilection. The tumor involves the endolymphatic sac, a portion of the intraosseous inner ear of the posterior petrous bone.
14°41′51″S 75°8′6″W. / 14.69750°S 75.13500°W / -14.69750; -75.13500. Location of Nazca lines in Peru. The Nazca lines ( / ˈnɑːzkə /, /- kɑː / [1]) are a group of geoglyphs made in the soil of the Nazca Desert in southern Peru. [2] They were created between 500 BC and 500 AD by people making depressions or shallow ...
HIF1A. Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 ( HIF-1) that is encoded by the HIF1A gene. [5] [6] [7] The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF. HIF1A is a basic helix-loop-helix PAS domain containing ...
KHL.ru. The Kontinental Hockey League ( KHL; Russian: Континентальная хоккейная лига (КХЛ), romanized : Kontinental'naya khokkeynaya liga) is an international professional ice hockey league founded in 2008. It comprises member clubs based in Russia (20), Belarus (1), Kazakhstan (1) and China (1) for a total of 23 ...
The Oberste Heeresleitung ( German pronunciation: [ˈoːbɐstə ˈheːʁəsˌlaɪtʊŋ], "Supreme Army Command", OHL) was the highest echelon of command of the army ( Heer) of the German Empire. In the latter part of World War I, the Third OHL assumed dictatorial powers and became the de facto political authority in the Empire.