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  2. GERD Not Responding to PPIs: What It Could Mean, Next Steps

    www.healthline.com/health/gerd/gerd-not...

    GERD may not respond to PPIs if they’re not taken as prescribed. PPIs should normally be taken 30–60 minutes before a meal, but potentially more than half of people take PPIs incorrectly. Most ...

  3. 5 Reasons Why GLP-1 Drugs like Ozempic and Wegovy May Not ...

    www.healthline.com/health-news/ozempic-glp-1...

    Takeaway. While many people will respond to Wegovy and Ozempic for weight loss, up to about 15% of people will not respond to the drugs. The reasons vary, from the need to make lifestyle tweaks ...

  4. When Your Pain Medication Isn't Working - WebMD

    www.webmd.com/.../when-pain-medications-not-working

    For example, antidepressants can help "calm down" the nervous system and make it less sensitive to the pain, Fine says. The anti- seizure drugs gabapentin and pregabalin can also be effective for ...

  5. Steps to Take If Your Oral Diabetes Medication Stops Working

    www.healthline.com/.../oral-medication-stops-working

    Add another drug. Metformin (Glucophage) is often the first drug you’ll take to control type 2 diabetes. If it stops working, the next step is to add a second oral drug. You have a few oral ...

  6. Why Can't I Get or Keep an Erection? - WebMD

    www.webmd.com/erectile-dysfunction/why-cant-i...

    Being overweight, getting too little exercise, and smoking all can work against the good blood flow that is key to erections. For some men, a little alcohol may help take the edge off. Yet too ...

  7. When Insulin Isn't Enough - WebMD

    www.webmd.com/diabetes/diabetes-insulin-not-enough

    Exercise. When you do it regularly, it's like adding another medicine to your care. It makes the insulin you take work better, and it removes the sugar, or glucose, from your blood. It also helps ...

  8. What Is the Safest Drug for Erectile Dysfunction? - Healthline

    www.healthline.com/health/what-is-the-safest...

    A typical dose of tadalafil is about 10 mg and starts working after about 30 minutes. In some cases, you may need to wait up to 4 hours before you start noticing the effects .

  9. What Can I Do When Immunotherapy Stops Working? - WebMD

    www.webmd.com/cancer/immunotherapy-not-working

    Immunotherapy is a treatment that helps your body's immune system fight cancer. It's approved to treat certain kinds, including some types of lymphoma, leukemia, breast cancer, and lung cancer. It ...