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Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc ( MYC ), l-myc ( MYCL ), and n-myc ( MYCN ). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc .
www .nm .org. Northwestern Medicine formerly Northwestern Memorial Healthcare, is a non-profit healthcare system affiliated with the Northwestern University Feinberg School of Medicine, in Chicago, Illinois. Members include research hospitals, acute care facilities, and academic centers. Northwestern Medicine's flagship hospital is the ...
t. e. There are 33 counties in the U.S. state of New Mexico . The New Mexico Territory was organized in September 1850. The first nine counties in the territory to be created, in 1852, were Bernalillo, Doña Ana, Rio Arriba, San Miguel, Santa Ana, Santa Fe, Socorro, Taos, and Valencia Counties. Mora County was created in 1860.
The MYCN gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix ( bHLH) domain. This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. [5] N-Myc is highly expressed in the fetal brain and is critical for normal brain development.
64685 Ensembl ENSG00000123609 ENSMUSG00000026946 UniProt Q13287 O35309 RefSeq (mRNA) NM_004688 NM_001141948 NM_001141949 NM_019401 RefSeq (protein) NP_004679 NP_001135420 NP_001135421 NP_062274 Location (UCSC) Chr 2: 151.27 – 151.29 Mb Chr 2: 51.84 – 51.86 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse N-myc-interactor also known as N-myc and STAT interactor is a protein that in ...
58805 Ensembl ENSG00000009950 ENSMUSG00000005373 UniProt Q9NP71 Q99MZ3 RefSeq (mRNA) NM_032951 NM_032952 NM_032953 NM_032954 NM_032994 NM_021455 NM_001359237 RefSeq (protein) NP_116569 NP_116570 NP_116571 NP_116572 NP_067430 NP_001346166 Location (UCSC) Chr 7: 73.59 – 73.62 Mb Chr 5: 135.12 – 135.17 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carbohydrate-responsive element ...
The N-myc internal ribosome entry site (IRES) is an RNA element found in the n-myc gene. The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis. n-myc mRNA has an alternative method of translation via an internal ribosome entry site where ribosomes are recruited to the IRES ...
Function. Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor.