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Glutamate–cysteine ligase (GCL) EC 6.3.2.2 ), previously known as γ-glutamylcysteine synthetase (GCS), is the first enzyme of the cellular glutathione (GSH) biosynthetic pathway that catalyzes the chemical reaction : L -glutamate + L -cysteine + ATP γ-glutamyl cysteine + ADP + P i. GSH, and by extension GCL, is critical to cell survival.
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Glutathione synthetase ( GSS) ( EC 6.3.2.3) is the second enzyme in the glutathione (GSH) biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine, to form glutathione. [2] Glutathione synthetase is also a potent antioxidant.
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Glutathione (GSH, / ˌ ɡ l uː t ə ˈ θ aɪ oʊ n /) is an organic compound with the chemical formula HOCOCH(NH 2)CH 2 CH 2 CONHCH(CH 2 SH)CONHCH 2 COOH. It is an antioxidant in plants , animals , fungi , and some bacteria and archaea .
The main types are: Drug-drug interaction. This is when a medication reacts with one or more other drugs. For example, taking a cough medicine ( antitussive) and a drug to help you sleep (sedative ...
Since the 1990s, the diabetes community has relied on the hemoglobin A1C to evaluate average glucose levels over the course of 3 months. But with modern CGM technology, a newer metric known as the ...
99 milligrams per deciliter (mg/dL) or lower is normal. 100 to 125 mg/dL may mean you have prediabetes. 126 mg/dL or higher may indicate diabetes. In the diagnosis of diabetes, healthcare ...
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