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In molecular biology, intercellular adhesion molecules ( ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events. [1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5.
VCAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines.
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation.
Multiple sclerosis. In multiple sclerosis (MS), the VLA-4 integrin is essential in the processes by which T-cells gain access to the brain. It allows the cells to penetrate the blood brain barrier that normally restricts immune cell access. It has been found that the severity of MS is positively correlated with the expression of alpha 4. [6]
Soluble cell adhesion molecules ( sCAM s) are a class of cell adhesion molecule (CAMs - cell surface binding proteins) that may represent important biomarkers for inflammatory processes involving activation or damage to cells such as platelets and the endothelium . They include soluble isoforms of the cell adhesion molecules ICAM-1, VCAM-1, E ...
Cameron Jerrell Newton [1] (born May 11, 1989) [2] is an American football quarterback who has played in the National Football League (NFL) for 11 seasons. Nicknamed " Super Cam ", [3] he is the NFL leader in career quarterback rushing touchdowns and second in career quarterback rushing yards. Following a stint with the Florida Gators, Newton ...
ICAM-1 ( Intercellular Adhesion Molecule 1) also known as CD54 ( C luster of D ifferentiation 54) is a protein that in humans is encoded by the ICAM1 gene. [5] [6] This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b ...
IgSF CAMs (Immunoglobulin-like Cell Adhesion Molecules) are cell adhesion molecules that belong to Immunoglobulin superfamily. [1] It is regarded as the most diverse superfamily of CAMs. This family is characterized by their extracellular domains containing Ig-like domains. The Ig domains are then followed by Fibronectin type III domain repeats ...