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The symptoms of thalassemia can vary. Some of the most common ones include: bone deformities, especially in the face. dark urine. delayed growth and development. excessive tiredness and fatigue ...
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β thalassemia intermedia is caused by a β + /β o or β + /β + genotype. In this form, some hemoglobin A is produced; β thalassemia minor is caused by a β/β o or β/β + genotype. Only one of the two β globin alleles contains a mutation, so β chain production is not terribly compromised and patients may be relatively asymptomatic.
Hemoglobin H disease is a genetic disorder resulting in absent or impaired production of the α-globin protein, a normal component of the hemoglobin. The disease occurs when the α-globin gene expression is reduced to less than 30% of the normal expression. [2] In a healthy individual there are four copies of the gene which encode the alpha ...
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Beta thalassemia intermedia. This is a moderate form of thalassemia. You may need treatment and blood transfusions, so your body has healthy hemoglobin and red blood cells. Beta thalassemia major ...
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Many symptoms of the more severe forms of alpha- and beta-thalassemia are quite similar. They stem from the complications of anemia, hemolysis, and excess iron. Alpha-thalassemia major is usually ...