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Von Hippel–Lindau disease ( VHL ), also known as Von Hippel–Lindau syndrome, is a rare genetic disorder with multisystem involvement. [3] It is characterized by visceral cysts and benign tumors with potential for subsequent malignant transformation. It is a type of phakomatosis that results from a mutation in the Von Hippel–Lindau tumor ...
The Von Hippel–Lindau tumor suppressor also known as pVHL is a protein that, in humans, is encoded by the VHL gene. Mutations of the VHL gene are associated with Von Hippel–Lindau disease, which is characterized by hemangioblastomas of the brain, spinal cord and retina. It is also associated with kidney and pancreatic lesions.
Epidemiology. This is a very rare tumor, since only about 1 in 35,000 to 40,000 people have VHL, of whom about 10% have endolymphatic sac tumors. Patients usually present in the 4th to 5th decades without an gender predilection. The tumor involves the endolymphatic sac, a portion of the intraosseous inner ear of the posterior petrous bone.
All-Russian Hockey League. The All-Russian Hockey League (VHL) [1] [2] (Russian: Всероссийская хоккейная лига (ВХЛ), Vserossiyskaya hokkeinaya liga (VHL) ), also known as the Major Hockey League [3] [4] or Higher Hockey League ( HHL ), [5] is a professional ice hockey league in Eurasia, and the second highest level ...
Oncology. Hemangioblastomas, or haemangioblastomas, are vascular tumors of the central nervous system that originate from the vascular system, usually during middle age. Sometimes, these tumors occur in other sites such as the spinal cord and retina. [1] They may be associated with other diseases such as polycythemia (increased blood cell count ...
Pancreatic serous cystadenoma is a benign tumour of the pancreas. [2] It is usually solitary and found in the body or tail of the pancreas, and may be associated with von Hippel–Lindau syndrome. [2] In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and the pancreatic ...
KHL.ru. The Kontinental Hockey League ( KHL; Russian: Континентальная хоккейная лига (КХЛ), romanized : Kontinental'naya khokkeynaya liga) is an international professional ice hockey league founded in 2008. It comprises member clubs based in Russia (20), Belarus (1), Kazakhstan (1) and China (1) for a total of 23 ...
The All-Russian Hockey League B or VHL-B ( Russian: Первенство Всероссийской хоккейной лиги (ВХЛ-Б), Pervenstvo Vserossiyskoy hokkeynoy ligi) is an ice hockey league in Russia. It stands at the third-tier of the Russian ice hockey pyramid, below the second-level VHL and the top-tier KHL .