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DMG-PEG 2000. Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). DMG-PEG 2000 is a synthetic lipid formed by the PEGylation of myristoyl diglyceride. It is used to manufacture lipid nanoparticles that are used in mRNA vaccines, [1] and in particular forms part of the drug delivery ...
PEGylation is the process of attaching the strands of the polymer PEG to molecules, most typically peptides, proteins, and antibody fragments, that can improve the safety and efficiency of many therapeutics. [9][10] It produces alterations in the physiochemical properties including changes in conformation, electrostatic binding, hydrophobicity ...
The siRNA active component of Patisiran is formulated into lipid nanoparticles, which protect the RNA and facilitate its delivery to target tissues. The lipid nanoparticle formulation includes buffer components, as well as the lipid components DLin-MC3-DMA, Distearoylphosphatidylcholine, cholesterol, and the PEGylated lipid DMG-PEG 2000.
Side Effects. Nausea, abdominal cramping, or gas may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. If your doctor has directed you to use this ...
Uses. PEG (polyethylene glycol) with electrolyte is used to clean out the intestines before certain bowel exam procedures such as colonoscopy or barium enema X-rays. It is a laxative that works by ...
Polyethylene glycol (PEG; / ˌpɒliˈɛθəlˌiːn ˈɡlaɪˌkɒl, - ˈɛθɪl -, - ˌkɔːl /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. The structure of PEG is ...
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