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DMG-PEG 2000. Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). DMG-PEG 2000 is a synthetic lipid formed by the PEGylation of myristoyl diglyceride. It is used to manufacture lipid nanoparticles that are used in mRNA vaccines, [1] and in particular forms part of the drug delivery ...
PEGylation is the process of attaching the strands of the polymer PEG to molecules, most typically peptides, proteins, and antibody fragments, that can improve the safety and efficiency of many therapeutics. [9][10] It produces alterations in the physiochemical properties including changes in conformation, electrostatic binding, hydrophobicity ...
Dimethylglycine is an essential amino acid, which means that the body cannot make this chemical on its own. It must be consumed in the diet. It is found in grains and meats and can also be taken ...
SM-102 is a synthetic amino lipid which is used in combination with other lipids to form lipid nanoparticles. [1] These are used for the delivery of mRNA-based vaccines, [2][3][4] and in particular SM-102 forms part of the drug delivery system for the Moderna COVID-19 vaccine. [5][6][7] Lipid nanoparticles are an extension of earlier RNA ...
Uses. PEG (polyethylene glycol) with electrolyte is used to clean out the intestines before certain bowel exam procedures such as colonoscopy or barium enema X-rays. It is a laxative that works by ...
Side Effects. Nausea, abdominal cramping, or gas may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. If your doctor has directed you to use this ...
Thimerosal helps prevent and kill dangerous bacteria and fungi in the vial. Thimerosal contains mercury, which can be toxic in large doses. There isn’t enough evidence to show the small amount ...
The siRNA active component of Patisiran is formulated into lipid nanoparticles, which protect the RNA and facilitate its delivery to target tissues. The lipid nanoparticle formulation includes buffer components, as well as the lipid components DLin-MC3-DMA, Distearoylphosphatidylcholine, cholesterol, and the PEGylated lipid DMG-PEG 2000.
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