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Alzheimer's Disease Neuroimaging Initiative. Alzheimer's Disease Neuroimaging Initiative ( ADNI) is a multisite study that aims to improve clinical trials for the prevention and treatment of Alzheimer's disease (AD). [1] This cooperative study combines expertise and funding from the private and public sector to study subjects with AD, as well ...
The University of Pennsylvania Smell Identification Test (UPSIT) is a test that is commercially available for smell identification to test the function of an individual's olfactory system . Known for its accuracy among smell identification tests it is considered to be one of the most reliable (r=.94) and trusted. [1]
Scientific researchers use it to measure benefits from a given therapy in a more unified and accepted rating system. Neurologists also use it in clinical practice to follow the progression of their patients' symptoms in a more objective manner. Following the UPDRS scores over time provides insight into the patient's disease progression.
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Immune privilege. Certain sites of the mammalian body have immune privilege (no immunity), meaning they are able to tolerate the introduction of antigens without eliciting an inflammatory immune response. Tissue grafts are normally recognised as foreign antigens by the body and attacked by the immune system. However, in immune privileged sites ...
Clinical trials happen in several phases during which different questions are asked. Each phase builds on the results of previous phases. Keep reading to learn more about what happens during each ...
UDN was established in 2014 with seven clinical sites located at medical institutions across the United States. As of 2019, twelve clinical sites are open. As of 2019, twelve clinical sites are open. Shared resources include a central biorepository, sequencing core, metabolomics core, and animal research centers.
Monitoring in clinical trials. Clinical monitoring is the oversight and administrative efforts that monitor a participant's health and efficacy of the treatment during a clinical trial. Both independent and government-run grant-funding agencies, such as the National Institutes of Health (NIH) [1] and the World Health Organization (WHO), [2 ...